Exploiting RNA Export as a Novel Treatment Strategy for Cancer

Abstract

The purpose of this project is to understand a new type of drug called dBET and its effects on breast cancer. We have recently made the exciting observation that this drug works in a way that was not previously appreciated, that may explain why the drug dBET is effective in killing tumor cells. We believe that this new function can be exploited to treat breast cancers, including the “triple-negative” subtype that has particularly bad prognosis, partly due to lack of treatment options.

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